2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141059
    Cy5-PEG5-azide bromide 98.76%
    Cy5-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Cy5-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Cy5-PEG5-azide bromide
  • HY-130531
    NH-bis(C2-PEG2-NH-Boc) 2182601-69-8 99.93%
    NH-bis(C2-PEG2-NH-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH-bis(C2-PEG2-NH-Boc)
  • HY-120918
    NH2-PEG7 1425973-14-3 98.0%
    NH2-PEG7 is a PROTAC linker, which refers to the PEG composition. NH2-PEG7 can be used in the synthesis of the PROTAC PARP1 degrader iRucaparib-AP6.
    NH2-PEG7
  • HY-134696
    Azido-PEG6-CH2COOH 880129-82-8 ≥98.0%
    Azido-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-CH2COOH
  • HY-117519
    Amino-Tri-(carboxyethoxymethyl)-methane 174362-95-9 98.0%
    Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-Tri-(carboxyethoxymethyl)-methane
  • HY-140076
    endo-BCN-PEG2-alcohol 1807501-85-4 98.0%
    endo-BCN-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG2-alcohol is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG2-alcohol
  • HY-141118
    Boc-NH-PEG3-NHS ester 2250216-93-2 98.0%
    Boc-NH-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG3-NHS ester
  • HY-141105
    m-PEG11-NHS ester
    m-PEG11-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG11-NHS ester
  • HY-140856
    Azido-PEG5-triethoxysilane
    Azido-PEG5-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-triethoxysilane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-triethoxysilane
  • HY-120587
    Bis-PEG6-acid 119189-70-7 ≥98.0%
    Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bis-PEG6-acid
  • HY-141293
    Oleic-DBCO 2279951-78-7
    Oleic-DBCO is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Oleic-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Oleic-DBCO
  • HY-W096125
    Desthiobiotin-PEG4-propargyl 1951424-89-7
    Desthiobiotin-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Desthiobiotin-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Desthiobiotin-PEG4-propargyl
  • HY-126893
    Bis-PEG8-acid 1246189-43-4 98.0%
    Bis-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG8-acid
  • HY-140106
    Azido-PEG3-SS-PEG3-azide 1310827-27-0 99.29%
    Azido-PEG3-SS-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-SS-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-SS-PEG3-azide
  • HY-114995
    Tr-PEG2-OH 105589-77-3 99.45%
    Tr-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tr-PEG2-OH is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Tr-PEG2-OH
  • HY-130166
    Amino-PEG9-acid 1191079-83-0 98.0%
    Amino-PEG9-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG9-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Amino-PEG9-acid
  • HY-141169
    TCO-PEG8-NHS ester 2353409-95-5
    TCO-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    TCO-PEG8-NHS ester
  • HY-130378
    Propargyl-PEG7-alcohol 1422023-54-8
    Propargyl-PEG7-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG7-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG7-alcohol
  • HY-140907
    Biotin-PEG3-Mal 1431618-70-0 98.88%
    Biotin-PEG3-Mal is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG3-Mal
  • HY-140012
    Azido-PEG4-beta-D-glucose 1609083-15-9 99.86%
    Azido-PEG4-beta-D-glucose is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-beta-D-glucose is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-beta-D-glucose
PROTAC Linkers Isoform Comparison

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